Medical Health Information

Thyroid hormones corresponding to the natural form of thyroid hormone called T3 usually. This hormone plays a key role in young children, primarily for the development of its weight and size and his brain maturation. 

Liothyronine once given leads to an increase in tissue oxygen consumption (group of cells) of the body and the basal metabolic rate, that is to say, of all chemical reactions occurring more precisely biochemical inside the body, allowing some substances to develop (anabolism) or degrade (catabolism), releasing energy. 

Indications 

• Hypothyroidism (decreased secretion of thyroid hormones throughout the body) 
• Some goiters: condition characterized by a diffuse increase as the volume of the thyroid gland, causing an excessive secretion of thyroid hormones. During this disease appear tremors, increased heart rate, weight loss, anxiety, sweating, nervousness, etc. ... In this case, the contribution of thyroid hormone will slow TSH secretion (a hormone secreted by the pituitary gland and especially its anterior lobe; whose aim is to stimulate the functioning of the thyroid gland)?
• Coma Myxedema: water penetration through the skin, giving patients a puffy appearance. Puffiness with this weight gain is accompanied by a thickening of traits (dazed face) and a yellow straw. Skin dry and cold, never shows perspiration. These signs are accompanied by macroglossia (large increase in the volume of the tongue) and a hoarse voice.
• Some thyroiditis (inflammation of the thyroid) chronic 
• Thyroid adenocarcinoma: tumor causing malignant tissue resembling glandular tissue, reproducing roughly the normal structure of the glands and mucous membranes (layer of cells covering the hollow organs in contact with air). In other words, adenocarcinoma is a malevolent tumor that develops at the expense of glandular tissue. Adenocarcinoma should not be confused with adenoma, a benign tumor affecting a gland. 

Dosage 

• In untreated hypothyroidism, hormone-replacement therapy will be established gradually and with caution. The initial dose is 1/4 tablet per day or 1/2 tablet per day, then the daily dose is increased stepwise every week, according to the clinical and laboratory findings. The optimal dose of substitution varies from one individual to another.
• In other indications, dosage is variable and must be individualized for each patient depending on the pathology, clinical and biological. 

Cons-indications 

• Hyperthyroidism, Graves' disease 
• Achievement uncompensated heart 
• Pathology of coronary (cons-indication)
• Arrhythmia 

Precautions 

It is necessary to monitor coronary disorders and particularly the cardiac rhythm disorders. The administration should be cautious in the elderly, or when there is a chronic myxoedema or diabetes mellitus. 

In the presence of hypothyroidism of pituitary origin or in renal secretion of adrenocortical hormone, it is first necessary to correct these disorders before administering thyroid hormones. 

Adverse 

There may, in case of overdose, signs of hyperthyroidism, such as: 

• Thinning excessive
• Increased body temperature 
• Headache
• Diarrhea
• Pain in the chest
• Myocardial infarction
• Insomnia
• Irritability
• Allergic reaction to the skin 
• Sweating
• Earthquakes
• Cardiovascular disorders like tachycardia (rapid heartbeat)
• Arrhythmia 

Drug Interactions 

Potentiate the action of anticoagulants, which should reduce the dose Prudence with insulin, hypoglycemic agents (drugs to lower blood sugar in the blood) and tricyclic antidepressants called. 

In case of poisoning, symptoms appear about one week after ingestion. It is abdominal pain, nausea, insomnia, vomiting, anxiety, agitation, rapid heartbeat, sweating, palpitations, high blood pressure or on the contrary, hypotension, increased skin temperature, and sometimes convulsions.