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Differential Diagnosis Of Parkinson's Disease

Some diseases can be confused with Parkinson's disease.

These are mainly:

  • Essential tremor.
  • Parkinsonism with hypoventilation and depression. This is Perry syndrome during this disease, which is hereditary and whose transmission is done according to the dominant mode (it is sufficient that one of the parents carries the genetic abnormality that offspring had the disease), there is the occurrence of apathy (disinterest) of a particular type (athymhormie) on the other hand, the patient hypoventilation (decreased ventilation) of central origin (due to a disturbance of the central nervous system). This condition, which begins in adults has a poor outcome in a few years. Biopsy performed in the patient who died showed the presence of a very large loss of neurons in the locus Niger but also in other locations in the brain (locus ceruleus, ventral area tegmental). Compared with Parkinson's disease, in that other neurological disease, there has not been the presence of Lewy bodies or in small numbers.
  • Parkinsonian syndromes associated occurring during certain neurological diseases such as Alzheimer's disease, Creutzfeld-Jacob, Steel-Richardson-Olszewski syndrome, Shy-Drager syndrome, Fahr's disease, Huntington, olio-onto-cerebellar atrophy.
  • Dementia with Lewy bodies.
Other syndromes

  • Parkinsonian syndrome posted neuroleptics ( butyrophenones, phenothiazines ), but also atypical antipsychotics and neuroleptics hidden (e.g. Primperan: Metoclopramide). It has besides been described after the use of certain herbs (including kava ).
  • Lewy body disease: parkinsonism in the elderly beginner quickly associated with cognitive disorders, attention disorders, sleep and visual hallucinations. 
  • Poisoning: exposure to pesticides (common), MPTP ( addiction ) 
  • Manganism: Chronic intoxication manganese by inhalation in certain occupations (welders, etc.) or ingestion (manganese content too much water) can cause a parkinsonian syndrome and exceptionally:

  • Wilson' disease: Diagnosis to evoke in young patients with a family history.
  • Progressive supranuclear palsy (PSP) or disease Steele-Richardson-Olszewski. 
  • Multiple system atrophy: extrapyramidal signs associated with more or less autonomic, pyramidal signs (impotence, orthostatic hypotension) or cerebellar (balance disorders). 
  •  Corticobasal degeneration: rare condition resulting in apraxia, unilateral extrapyramidal signs.
  • Parkinson disease: stroke affecting the basal ganglia. The distinction between a vascular parkinsonism and Parkinson's disease can be difficult on [Who?] can help olfactory tests showing better responses when the cause is vascular. 
  • Hydrocephalus normal pressure

 Parkinsonian tremor not 

 There are more than twenty other causes of earthquakes, including the most common, the essential tremor, a tremor during movement (or in maintaining attitude postural tremor), not rest, as parkinsonian tremor. Neurologists to confirm the existence of a specific pathology is a disease.

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