What is Osler's disease?
Osler's disease is an inherited blood vessel disease that causes bleeding from the mucous membranes of the nose, gastrointestinal tract, lungs or urinary tract. Patients may also have abnormal blood vessels in the brain. Other names for the condition are Osler-Rendu-Weber disease or hereditary hemorrhagic telangiectasia.
The condition can be found throughout the world. There is no gender difference. The incidence reported from the Netherlands Antilles 1:200, 1:8345 in France at 1:39.000 in northern England. We have not Norwegian numbers.
Osler's disease is a disease in which there are signs throughout the body. There is a change in the body's smallest blood vessels, capillaries. The disease is characterized by the expansion of these small blood vessels (telangiectasia) and other malformations of the skin, mucous membranes and internal organs. And there is an increased bleeding tendency.
The condition is inherited (autosomal dominant), which means that there are changes in the genetic material, genes.
Most typically, they appear pathological changes of the skin and mucous membranes, and may include lead to nose bleeding. Less frequent but more serious, are changes in other organs such as lungs and brain.
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